Dominancia de alelos silvestres de mutaciones kdr del dominio II del VGSC de Aedes aegypti de Culiacán, Sinaloa, México.: Dominance of Wild-Type Alleles of kdr Mutations in Domain II of the VGSC in Aedes aegypti from Culiacán, Sinaloa, Mexico

Praxedis  Félix-Alcalá; Elisa A.  Camacho-Ureta; Delia M.  Becerril-Camacho; Sergio A.  Durán-Pérez; Annete I. Apodaca-Medina

doi:10.63622/RBS.2402

Authors

Praxedis Félix-Alcalá Licenciatura en Ciencias Biomédicas, Universidad Autónoma de Occidente, Unidad Regional Culiacán, Boulevard Lola Beltrán S/N, 4 de Marzo, C.P. 80054 Culiacán, Sinaloa, México. Author https://orcid.org/0009-0006-5626-2247
Elisa A. Camacho-Ureta Unidad de Investigaciones en Biotecnología Biomédica, Universidad Autónoma de Occidente, Unidad Regional Cu-liacán, Boulevard Lola Beltrán S/N, 4 de Marzo, C.P. 80054 Culiacán, Sinaloa, México. Author https://orcid.org/0000-0003-3596-4806
Delia M. Becerril-Camacho Unidad de Investigaciones en Biotecnología Biomédica, Universidad Autónoma de Occidente, Unidad Regional Cu-liacán, Boulevard Lola Beltrán S/N, 4 de Marzo, C.P. 80054 Culiacán, Sinaloa, México. Author https://orcid.org/0009-0007-6329-7752
Sergio A. Durán-Pérez Posgrado en Biotecnología, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Sinaloa, Boulevard Universitarios S/N, Ciudad Universitaria, C.P. 80013, Culiacán, Sinaloa, México. Author https://orcid.org/0000-0002-1009-2020
Annete I. Apodaca-Medina Unidad de Investigaciones en Biotecnología Biomédica, Universidad Autónoma de Occidente, Unidad Regional Cu-liacán, Boulevard Lola Beltrán S/N, 4 de Marzo, C.P. 80054 Culiacán, Sinaloa, México. Author https://orcid.org/0000-0003-4936-1731

DOI:

https://doi.org/10.63622/RBS.2402

Keywords:

Aedes aegypti, kdr, VGSC, resistance, pyrethroids

Abstract

Aedes aegypti is the primary vector of arboviruses such as Dengue. Currently, strategies to reduce the vector population are based on the use of insecticides such as organophosphates, organochlorines, carbamates, and pyrethroids, which have contributed to reducing the vector population. However, A. aegypti has developed resistance to compounds like permethrin and deltamethrin, which has been associated with the presence of polymorphisms (SNPs) in the voltage-gated sodium channel (VGSC) gene, known as kdr mutations, which block the action of pyrethroids on the sodium channel. In this study, the kdr mutations L982W, S989P, A1007G, and I1011M/V were genotyped through sequencing. The results show that the analyzed A. aegypti population exhibits a wild-type genotype for the mentioned mutations, suggesting that other kdr mutations in different domains may be present in our population, conferring resistance to A. aegypti

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