Impact of the Aqueous Extract of Bromelia pinguin on Cell Death Mechanisms in the MDA-MB-231 Breast Cancer Cell Line
Impact of the Aqueous Extract of Bromelia pinguin on Cell Death Mechanisms in the MDA-MB-231 Breast Cancer Cell Line
DOI:
https://doi.org/10.63622/RBS.2405Keywords:
Cancer, Breast cancer, phytochemicals, Bromelia penguinAbstract
Breast cancer is a major global public health issue. In 2022, approximately 2.3 million new cases were reported, making it the most common cancer among women. In Mexico, it is the leading cause of cancer-related death in women. Several phytochemicals have shown potential to induce cell death and inhibit tumor growth. B. pinguin, a tropical plant from the Bromeliaceae family, has been traditionally used as an anti-inflammatory, antitussive, and antimicrobial agent. This study aimed to evaluate the effect of aqueous B. pinguin extract on cell viability and apoptosis in the MDA-MB-231 breast cancer cell line. Viability assays and Western blot analysis of key apoptotic proteins were performed. Results indicate that at the tested concentration, the extract does not induce apoptosis, as evidenced by partial processing of pro-caspase-3 and the absence of PARP1 cleavage. This study represents a preliminary exploration of the antitumor potential of Bromelia pinguin and highlights the need for further research.
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